GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs17401966 | 1 | rs12136376 | chr1:10296452 | PGD | chr1:10459085-10480200:+ | 0.19 | 5.51 | 4.42E-8 | Hepatocellular carcinoma |
| BRCA | cis | rs6683977 | 1 | rs12137080 | chr1:66766185 | PDE4B | chr1:66258193-66840261:+ | -0.13 | -3.63 | 0.000298 | Acute lymphoblastic leukemia (childhood) |
| BRCA | cis | rs10927875 | 1 | rs12138117 | chr1:16305279 | CLCNKA | chr1:16345370-16360544:+ | -0.21 | -5.27 | 1.67E-7 | Dilated cardiomyopathy |
| BRCA | cis | rs12143789 | 1 | rs12138343 | chr1:119495317 | WARS2 | chr1:119573841-119683295:- | 0.26 | 4.81 | 1.75E-6 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs6684514 | 1 | rs12139321 | chr1:156230429 | BGLAP | chr1:156182784-156213112:+ | 0.18 | 4.61 | 4.59E-6 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12139321 | chr1:156230429 | C1orf85 | chr1:156259882-156265449:- | -0.12 | -3.62 | 0.000304 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12139321 | chr1:156230429 | CCT3 | chr1:156278752-156308195:- | -0.12 | -3.55 | 0.000402 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs2275426 | 1 | rs12139630 | chr1:46350935 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.84 | 1.73E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12139630 | chr1:46350935 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.57 | 0.000371 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12139630 | chr1:46350935 | MUTYH | chr1:45794915-45806142:- | 0.13 | 4.98 | 7.32E-7 | Body mass index |
| BRCA | cis | rs12143789 | 1 | rs12139690 | chr1:119491316 | WARS2 | chr1:119573841-119683295:- | 0.27 | 4.96 | 8.21E-7 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs6696239 | 1 | rs12140848 | chr1:227776942 | ZNF678 | chr1:227751244-227910352:+ | 0.08 | 3.54 | 0.000412 | Height |
| BRCA | cis | rs6684514 | 1 | rs12141236 | chr1:156302575 | BGLAP | chr1:156182784-156213112:+ | 0.2 | 5.24 | 1.92E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12141236 | chr1:156302575 | CCT3 | chr1:156278752-156308195:- | -0.11 | -3.56 | 0.000391 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs17401966 | 1 | rs12141416 | chr1:10327867 | PGD | chr1:10459085-10480200:+ | 0.19 | 5.73 | 1.31E-8 | Hepatocellular carcinoma |